First off, I'm going to say that this is probably going be my last entry here. This blog was a long test run. I developed my writing style and skills from right after high school until now and it is time to say goodbye. This blog has always been a clusterfuck of content but with no theme. No driving force other than my need to write.
So here are where my efforts to have a theme led: Green Goddess & Secular Ministries
Hopefully, I'll see you there.
Love to Mah Peoples!
(Nenna)
+Lame Epiphanies+
Straight from the brain of a future genius.
Tuesday, February 21, 2012
Friday, December 16, 2011
Indigenous Vs. Scientific Soil Classification
The Western scientific approach to soil classification includes many elements of the indigenous methods of the Kayapo indian of Para Brazil (Cooper, Sparovek, Teramoto, & Vidal-Torrado, 2005). The reasons for classification between the two are similar and defining features of the classifications, themselves, are loosely in tune (Cooper, Sparovek, Teramoto, & Vidal-Torrado, 2005).
The major components of the Kapoyo classification are color, texture, moisture and mineral content. Kayapo classification is grouped according to the different combinations of those components (Cooper, Sparovek, Teramoto, & Vidal-Torrado, 2005). Western scientific classification adds to the depth of each classification, taking extra steps to clarify the particular minerals groups, organic material groups and organism groups within the various types of soils (“Soil survey laboratory,” n.d.). For example, folistic epipedon, a surface soil, consists mostly of mossy organic material but frangipan is a term that describes soil that is well drained, the specifications of which may vary (“Soil survey laboratory,” n.d.). By way of the Kayapo classification, minerals and moisture are the focus of texture classification and there either are or are not minerals or moisture within the soil, while organic material is not considered (Cooper, Sparovek, Teramoto, & Vidal-Torrado, 2005). More information is required to determine whether or not the Kayapo explore their soil to the depths with which Western science ventures, as Western scientific classification tends to list a range of color values for each soil classification, which is indicated by a number, unlike the Kayapo (“Soil survey laboratory,” n.d.).
The soil serves a purpose for agriculture here as well as with the Kayapo Indians. In Western culture forests are reduced or destroyed to cultivate land for farming or building because of the soil contained where forests occur naturally (Faiez, 1996). Conservation and living in harmony with the natural world is of the utmost importance to the indigenous people of Para Brazil (“Conservation international,” 2011). In the Amazon, the Kayapo collect and distribute the native soils to apetes or small islands used for reforestation that can be used for increasing biodiversity by attracting game and planting vegetation that can support the people as an integral part of the environment (Faiez, 1996).
References:
(2011). Conservation international. (2011). [0]. Retrieved from http://www.conservation.org/FMG/Pages/videoplayer.aspx?videoid=34
Cooper, M., Sparovek, G., Teramoto, E., & Vidal-Torrado, P. (2005). Learning soil classification with the kayapo indians. Agricultural Science, 64(6), 604-606.
Faiez, S. (1996, July 09). When the local people know best. New Straights Times, p. 2.
U.S. Department of Agriculture, Natural Resource Conservation Service. (n.d.). Soil survey laboratory methods manual (42). Retrieved from website: ftp://ftp-fc.sc.egov.usda.gov/NSSC/Lab_Methods_Manual/SSIR42_2004_view.pdf
Picture Source:
Verswijver, G.. KayapĆ³. N.p., 2002. Web. 16 Dec 2011..
The major components of the Kapoyo classification are color, texture, moisture and mineral content. Kayapo classification is grouped according to the different combinations of those components (Cooper, Sparovek, Teramoto, & Vidal-Torrado, 2005). Western scientific classification adds to the depth of each classification, taking extra steps to clarify the particular minerals groups, organic material groups and organism groups within the various types of soils (“Soil survey laboratory,” n.d.). For example, folistic epipedon, a surface soil, consists mostly of mossy organic material but frangipan is a term that describes soil that is well drained, the specifications of which may vary (“Soil survey laboratory,” n.d.). By way of the Kayapo classification, minerals and moisture are the focus of texture classification and there either are or are not minerals or moisture within the soil, while organic material is not considered (Cooper, Sparovek, Teramoto, & Vidal-Torrado, 2005). More information is required to determine whether or not the Kayapo explore their soil to the depths with which Western science ventures, as Western scientific classification tends to list a range of color values for each soil classification, which is indicated by a number, unlike the Kayapo (“Soil survey laboratory,” n.d.).
The soil serves a purpose for agriculture here as well as with the Kayapo Indians. In Western culture forests are reduced or destroyed to cultivate land for farming or building because of the soil contained where forests occur naturally (Faiez, 1996). Conservation and living in harmony with the natural world is of the utmost importance to the indigenous people of Para Brazil (“Conservation international,” 2011). In the Amazon, the Kayapo collect and distribute the native soils to apetes or small islands used for reforestation that can be used for increasing biodiversity by attracting game and planting vegetation that can support the people as an integral part of the environment (Faiez, 1996).
References:
(2011). Conservation international. (2011). [0]. Retrieved from http://www.conservation.org/FMG/Pages/videoplayer.aspx?videoid=34
Cooper, M., Sparovek, G., Teramoto, E., & Vidal-Torrado, P. (2005). Learning soil classification with the kayapo indians. Agricultural Science, 64(6), 604-606.
Faiez, S. (1996, July 09). When the local people know best. New Straights Times, p. 2.
U.S. Department of Agriculture, Natural Resource Conservation Service. (n.d.). Soil survey laboratory methods manual (42). Retrieved from website: ftp://ftp-fc.sc.egov.usda.gov/NSSC/Lab_Methods_Manual/SSIR42_2004_view.pdf
Picture Source:
Verswijver, G.. KayapĆ³. N.p., 2002. Web. 16 Dec 2011.
Monday, November 28, 2011
The Northern Copperhead, WV Native, Pit Viper.
Appearance:
The northern copperhead or the agkistrodon contortrix mokasen (“Snakes of WV,” 2006), from the kingdom animalia (“Copperhead snakes, 2011), is one of only two venomous snakes in the state of West Virginia (“Snakes of WV,” 2006). This reptilian beauty is rightly named for her large, triangular, copper-colored head. The underbelly of the northern copperhead is a pinkish color, while her back is covered in an hour glass pattern, wider on the sides and narrow through the middle, a reddish brown in color, serving as a camouflage from larger predators (“Snakes of WV,” 2006). Copperheads are classified as pit vipers, named for the indentations which sense heat located between the eye and nostril on both sides of the face (Henricks, 2008).
Young copperheads are recognized by the yellow tip on their tail and are often much shorter in length (“Snakes of WV,” 2006). The average length of this West Virginia predator is around two feet for adults and around eight to ten inches at birth. The record length for the state is four and a half feet (“Some snakes of,”).
Temperament:
As is common among snakes, copperheads have jaws that are not fused together to accommodate for devouring sizable prey whole. It is difficult to sneak up on a copperhead unless they are getting ready to strike, for their sense of hearing is gained through vibrations in the jaw bone through the ground.
Copperheads are not known for a vicious demeanor and are not usually dangerous unless startled or threatened (“Some snakes of,”). Bites from a copperhead are very rarely lethal, though said to be incredibly painful. Venom is made up of a blend of saliva, proteins and enzymes, and that of a copperhead contain hemotoxins, which prevent blood from clotting and damages muscle tissue, as well as neurotoxins which attack the central nervous system (Henricks, 2008). The northern copperhead will strike from birth (“Some snakes of,”).
Environment:
The mountains of West Virginia are a perfect environment for this predator, as the biome of the agkistrodon contortrix mokasen is that of the deciduous forest however, copperheads are known to wander into domesticated areas, in part, because of their diets (Jathar, 2011).
Juvenile copperheads often live mainly on invertebrates before they reach full strength and speed, although adults are also known to seek out aquatic prey. Amphibians and reptiles, frogs, turtles and other snakes that are indigenous to the area, are also common menu items for both adult and juvenile. However, the older the copperheads become, the more they feast primarily on rodents such as mice and moles (“Copperhead snakes,” 2011).
It is the pursuit of rodents that is most likely the reason for domesticated spotting of the northern copperhead. They have been spotted around barns and buildings, city gardens, wood and sawdust piles, and in haystacks, all places one is likely to catch a mouse (“Some snakes of,”).
Life Cycle:
Adult copperheads generally shed once to thrice a year and will shed to heal infection and injury. Juveniles shed to accommodate growth as well as for healing (“Copperhead snakes,” 2011).
Northern copperhead mating season begins in February and ends in April. The age of sexual maturity is around the 4th year of life for both the male and female. A female will mate with a single male per season and can store the sperm he produces for several months. The act of mating can last for three to eight hours, the end of which involves the male fertilizing the female with one of several reproductive “spikes (“Copperhead snakes,” 2011).”
Gestation is typically three months and spawns between one and fourteen juveniles (“Some snakes of”). Copperheads are viviparous, meaning their births are live rather than hatched from eggs as with some species of snakes (“Copperhead snakes,” 2011).
During the winter copperheads will den with other copperheads as well as several other species of snakes, which could prove fatal to the copperhead as it is not uncommon for snakes to eat other species of snakes (“Copperhead snakes,” 2011).
References:
(2006). Snakes of west virginia. Elkins, WV: West Virginia Division of Natural Resources.
Copperhead snakes. (2011). Retrieved from http://www.animalcorner.co.uk/venanimals/ven_snakescopper.html
Hendricks, B. (2008, May 25). Watch where you walk, work, play wisdom, caution can help sportsmen avoid venomous bites. Arkansas Democrat-Gazette
Jathar, R. (2011, September 21). Deciduous forest animals. Retrieved from
http://www.buzzle.com/articles/deciduous-forest-animals.html
(n.d.). Some snakes of west virginia. Charleston, WV: West Virginia Department of Agriculture.
The northern copperhead or the agkistrodon contortrix mokasen (“Snakes of WV,” 2006), from the kingdom animalia (“Copperhead snakes, 2011), is one of only two venomous snakes in the state of West Virginia (“Snakes of WV,” 2006). This reptilian beauty is rightly named for her large, triangular, copper-colored head. The underbelly of the northern copperhead is a pinkish color, while her back is covered in an hour glass pattern, wider on the sides and narrow through the middle, a reddish brown in color, serving as a camouflage from larger predators (“Snakes of WV,” 2006). Copperheads are classified as pit vipers, named for the indentations which sense heat located between the eye and nostril on both sides of the face (Henricks, 2008).
Young copperheads are recognized by the yellow tip on their tail and are often much shorter in length (“Snakes of WV,” 2006). The average length of this West Virginia predator is around two feet for adults and around eight to ten inches at birth. The record length for the state is four and a half feet (“Some snakes of,”).
Temperament:
As is common among snakes, copperheads have jaws that are not fused together to accommodate for devouring sizable prey whole. It is difficult to sneak up on a copperhead unless they are getting ready to strike, for their sense of hearing is gained through vibrations in the jaw bone through the ground.
Copperheads are not known for a vicious demeanor and are not usually dangerous unless startled or threatened (“Some snakes of,”). Bites from a copperhead are very rarely lethal, though said to be incredibly painful. Venom is made up of a blend of saliva, proteins and enzymes, and that of a copperhead contain hemotoxins, which prevent blood from clotting and damages muscle tissue, as well as neurotoxins which attack the central nervous system (Henricks, 2008). The northern copperhead will strike from birth (“Some snakes of,”).
Environment:
The mountains of West Virginia are a perfect environment for this predator, as the biome of the agkistrodon contortrix mokasen is that of the deciduous forest however, copperheads are known to wander into domesticated areas, in part, because of their diets (Jathar, 2011).
Juvenile copperheads often live mainly on invertebrates before they reach full strength and speed, although adults are also known to seek out aquatic prey. Amphibians and reptiles, frogs, turtles and other snakes that are indigenous to the area, are also common menu items for both adult and juvenile. However, the older the copperheads become, the more they feast primarily on rodents such as mice and moles (“Copperhead snakes,” 2011).
It is the pursuit of rodents that is most likely the reason for domesticated spotting of the northern copperhead. They have been spotted around barns and buildings, city gardens, wood and sawdust piles, and in haystacks, all places one is likely to catch a mouse (“Some snakes of,”).
Life Cycle:
Adult copperheads generally shed once to thrice a year and will shed to heal infection and injury. Juveniles shed to accommodate growth as well as for healing (“Copperhead snakes,” 2011).
Northern copperhead mating season begins in February and ends in April. The age of sexual maturity is around the 4th year of life for both the male and female. A female will mate with a single male per season and can store the sperm he produces for several months. The act of mating can last for three to eight hours, the end of which involves the male fertilizing the female with one of several reproductive “spikes (“Copperhead snakes,” 2011).”
Gestation is typically three months and spawns between one and fourteen juveniles (“Some snakes of”). Copperheads are viviparous, meaning their births are live rather than hatched from eggs as with some species of snakes (“Copperhead snakes,” 2011).
During the winter copperheads will den with other copperheads as well as several other species of snakes, which could prove fatal to the copperhead as it is not uncommon for snakes to eat other species of snakes (“Copperhead snakes,” 2011).
References:
(2006). Snakes of west virginia. Elkins, WV: West Virginia Division of Natural Resources.
Copperhead snakes. (2011). Retrieved from http://www.animalcorner.co.uk/venanimals/ven_snakescopper.html
Hendricks, B. (2008, May 25). Watch where you walk, work, play wisdom, caution can help sportsmen avoid venomous bites. Arkansas Democrat-Gazette
Jathar, R. (2011, September 21). Deciduous forest animals. Retrieved from
http://www.buzzle.com/articles/deciduous-forest-animals.html
(n.d.). Some snakes of west virginia. Charleston, WV: West Virginia Department of Agriculture.
Tuesday, November 22, 2011
Conceiving after the age of 35
I thought this topic to be very fitting after my paper on stem cell research. It can be difficult for women to conceive later in life because ovulation is not always successful as we age. There is a chance of unintended pregnancy if no form of contraceptives are being used, consequently 60% of unintended pregnancies of women over the age of 40 end in abortion ("Getting pregnant during," 2011). For women over the age of 35 pursuing pregnancy in vitro fertilization and other forms of reproductive assistance are available. Here is what you should know if you are part of this demographic or love someone who is:
Risks of late gestation:
The longer a woman waits to conceive the higher risk the pregnancy she seeks. Complications are not just more likely for the woman, but also for the child.
Risks for mothers:
Women who become pregnant later in life are at risk for several health issues depending on how healthy they are at the time. Over the age of 35, particularly women who are overweight or practice poor eating habits, gestational diabetes is more common than in younger mothers-to-be, as well as preeclampsia (high blood pressure) and osteoporosis, a painful disorder of the bones (“Getting pregnant during,” 2011). According to cancer.gov, a website run by the National Cancer Institute, women having their first child after age 30 are at the highest risk of getting breast cancer. Breast cancer is attributed two hormones produced in the ovaries; progesterone and endogenous estrogen. Pregnancy in peak years of reproduction, as well as breast feeding, combat breast cancer by limiting the body’s levels of these hormones (“National cancer institute,” 2011).
Risks for babies:
Babies born to mothers over the age of 35 are at risk for still birth and miscarriage, and are also more likely to be born with low birth weight, in breech position or via a cesarean section(“Getting pregnant during,” 2011). Chromosomal abnormalities such as Down syndrome and open neural tube defects such as spina-bifida are also a higher risk for older mommies (LPCH, 2011).
Implemental advances in medical technology:
Assisted Reproductive Technology (ART):
ART is comprised of 3 main methods of fertilization; in vitro fertilization (IVF), gamete intrafallopian transfer (GIFT), and zygote intrafallopian transfer (ZIFT). Success rates are listed individually per clinic and can be found on the website for the Center for Disease Control and Prevention, but on average, depending on age, the success rate is 6-25% for a woman over the age of 30 (“In vitro fertilization, 2007).
IVF:
IVF is a very involved process that requires fertility medications and monitoring of egg release via ultrasound. Once eggs are produced, they are extracted and fertilized before an incubation period in which the ultimate goal is the procurement of usually several embryos. If expectations of egg fertility are low, sperm may be directly injected into eggs before incubation. This process is called an intractoplasmic sperm injection, or ICSI.
Less than a week after the gametes have begun dividing, multiple embryos are injected transvaginally with the help of an ultrasound machine for monitoring. Couples or single women seeking IVF may use their own gametes or those supplied by a donor (“In vitro fertilization, 2007).
GIFT & ZIFT:
GIFT & ZIFT offer alternatives to IVF but only make up for a combined total of less than 3.5% of ART in the US for aspiring mothers with fertility complications. GIFT is an injection of gametes into the fallopian tube of the mother with the idea of fertilization taking place there rather than in a lab. ZIFT is the injection of a zygote (created in the lab) into the fallopian tube via a laparoscopic surgery (“In vitro fertilization, 2007).
Screenings during pregnancy:
There are many screenings available to monitor the health of the mother and child during pregnancy and modern medicine currently offers several that benefit the 35+ mom.
The triple screen test is a blood screening that tests for hormones indicative of chromosomal abnormalities and open neural tube defects (ONTD), but amniocentesis and chorionic villus sampling (CVS) are more accurate (“Genetic testing during,” 2011). Amniocentesis is 99.4% accurate and is the testing of the amniotic fluid during the 15th to 20th week of pregnancy via a very fine needle through the abdomen, monitored by an ultrasound machine (LPCH, 2011). A CVS is every bit as accurate but is not capable of testing for ONTD. This procedure involves transvaginal or transabdominal procurement of a placenta sample at the 12th to 16th week of gestation, also monitored by ultrasound (LPCH, 2011).
Personal Opinion:
I had both of my children early but plan to conceive again later in life. How much later, I am uncertain. I think I am at less of a risk for most complications due to the fact that it will not be my first and because genetics are on our side.
For others, I support the right of anyone to pursue what makes them happy, risk or not. Pregnancy has risks for everyone, even when the odds are in our favor. I also support adoption and surrogacy. I feel the decision is with the mother once she is educated of the risks, but educated she should be before she makes any decisions.
References:
Genetic testing during pregnancy. (2011). Retrieved from http://www.womenshealthcaretopics.com/tests_during_pregnancy.htm
Getting pregnant during the menopausal years. (2011). Retrieved from http://www.epigee.org/menopause/pregnancy.html
In virto fertilization: Ifv. (2007, May 01). Retrieved from http://www.americanpregnancy.org/infertility/ivf.html
Lucile packard children's hospital. (2011). Retrieved from http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/pregnant/tests.html
National cancer institute. (2011, May 10). Retrieved from http://www.cancer.gov/cancertopics/factsheet/Risk/reproductive-history
Monday, November 21, 2011
The History & Future of Stem Cell Research
What are stem cells?
Stem cells occupy the bodies of mammals of all species, ages and sizes. Stem cells provide every cell, organ and tissue in the body with a foundation. The stem cells that remain in the body after it is formed and fully developed have exceptionally long lives in which they self-replicate and self-sustain to contribute to the normal regeneration needed in the body. In development, they are blank until programmed with a specialized function, such as producing a spleen or a heart, or building a skeletal system (“Questions and answers,” 2011). Embryonic stem cells are those found in the tissues of an embryo and all of the organs produced for healthy gestation. There are three types of “adult” stem cells, hematopoietic stem cells, which form blood, endothelial stem cells, which form the vascular system, and mesenchymal stem cells which form muscle, fibroblasts, bone, cartilage and fat (“Questions and answers,” 2011). Additionally there are pluripotent and multi-potent stem cells, the difference between which, being that pluripotent has a specialized function with regenerative qualities and multi-potent cells have the ability to differentiate, or become one of several tissues or organs (“Questions and answers, 2011).
Embryonic Stem Cells:
Embryonic stem cells (ESCs) possess a greater rate of regeneration and replication, they are considered to be more plastic than “adult” stem cells because of their natural effectiveness, considering that these are the cells responsible for composing an entire human body in around nine months. ESCs can be found in the blastocyst that is the product of the first week of conception (“Questions and answers,” 2011). Samples of this type are achieved through left over compositions of in-vitro fertilization (Green, 2001), although ESCs can also be found in amniotic fluid, baby teeth and umbilical cord blood through donors (“Questions and answers, 2011).
Hematopoietic Stem Cells:
Due to the extensive research on hematopoietic stem cells (HSCs), we know much more about them than any other “adult,” human stem cell. HSCs are the regenerative tissue of the circulatory and immune system, making them invaluable to modern medicine. HSCs have the capability to become any type of blood cell, based on research. These wonderfully malleable cells thrive for extended periods in bone marrow, and periodically circulate in the blood stream, dividing into progenitor cells, precursors to specialized cells. When all functions of HSC circulation are complete, the HSC regenerate, some complete the process of apoptosis (programmed cell death) and the rest return to the bone marrow. What separates the cells that preform apoptosis versus those who do not is currently a research unknown (“Hematopoietic Stem Cells,” 2011).
Why study stem cells?
In the scientific community the pursuit to understand the human body is an endless one. Every type of cell serves some purpose. The more the functions of human cells are understood, the more possibilities unfold for preventative and treatment measures for the many things that can go wrong within the body. The short answer is the medical benefits that stem cells can provide those in need.
A brief history of stem cell research:
In 1945 scientists were researching mice that were exposed to lethal doses of radiation. It was suspected that bone marrow possessed that ability to form new blood cells. The proof arose when scientists effectively preserved the poisoned mice by transplanting bone marrow from healthy mice. In 1985, a scientist by the name of Perkins did some research on the embryonic stem cells of mice. It was determined that all progenitor cells could be produced between mouse ESCs and hematopoietic growth factors, which cause hematopoiesis or the formation of all the blood cells within the body (“Hematopoietic stem cells,” 2011).
In the 1960’s, scientists Til and McCullough discovered regenerative qualities and plastic capabilities while analyzing bone marrow. In 1992, when the plasticity of HSCs and ESCs was still an uncertainty, the New York Blood Center began storing umbilical cord blood and placenta that would otherwise be discarded to begin research on human ESCs (“Hematopoietic stem cells,” 2011). In 1998 research teams in Johns Hopkins University and the University of Wisconsin, Madison successfully grew human stem cells in culture. Their efforts included the use of telomerase to prevent death of the cell line, easing the burden of time for further research, the result; “an immortal, pluripotent human stem cell culture (Green, 2011).”
Former President Bill Clinton had aspirations to fund stem cell research during his presidency, however, his term ended and with the arrival of George W. Bush in office, research was severely limited. In 2001 Bush limited funding to research on currently established ESC lines only, and vetoed against expansion of research for two years, consecutively (Townsend, 2008), despite Kerry’s campaign for funding new cell lines in the election of 2004 (Sharockman, 2010). In 2005 Korea allowed for the cloning of embryos with the intent of extracting cells for research. Here, began the pursuit of the scientific community in the U.S. and Japan to catch up (Sabin, 2005), followed by Israel, England and Australia (Lu, 2009). President Barack Obama favored the expansion of stem cell research as a senator and opened funding to research on new ESC lines in 2008 upon being appointed president (Lu, 2009).
Current treatments and practices involving HSC and ESC
HSC is currently being stored for some cancer patients, as a finalized treatment, while they undergo chemotherapy and take other cancer treatment drugs. Upon cleansing the body of cancerous cells, HSCs from the patient are reintroduced to promote healthy regeneration, division and apoptosis of the many cells in the blood (“Hematopoietic stem cells,” 2011).
Similarly, bone marrow is transplanted from match donors to promote hematopoiesis after chemotherapy in those being treated for leukemia and lymphoma. An alternative treatment to bone marrow transplant, Gleevec, was introduced in 2001 as a means to encourage apoptosis in infected white blood cells. Results of clinical trials for Gleevec are currently an unknown (“Hematopoietic stem cells,” 2011).
Bone marrow transplants can have a positive impact in many inherited blood disorders, such as sickle-cell anemia, osteoporosis, and Hunter’s syndrome. Treatments for muscular dystrophy are also currently in clinical trials (“Hematopoietic stem cells,” 2011).
Challenges for stem cell research:
Challenges for the researcher:
There is one hematopoietic stem cell to every ten to fifteen thousand (1/10,000-15,000) bone marrow cells and to every hundred thousand blood cells in circulation of the circulatory system (“Hematopoietic stem cells,” 2011). There is no current efficient method of distinguishing between “adult” hematopoietic stem cells and other blood cells, therefore identifying them can be incredibly difficult. To add an element of challenge, without host, cells do not continue to regenerate and divide for long. Proliferation, or continuing the life of a cell outside of a host, can more easily be achieved, however, if a method of identification became available (“Hematopoietic stem cells,” 2011).
Challenges for the research:
As previously mentioned, funding has not always been readily available in the U.S. for all forms of stem cell research necessary to advance the way the scientific community aspires to in medicine. Embryonic stem cells are best extracted from destroying an embryo, which raises moral and ethical question, particularly among religious groups and those affiliated. That affiliation is likely the reason for Bush’s 2001 bill as well as his multiple vetoes against opening funds for new embryonic stem cell lines.
In matters involving conception, gestation and early development, the public is often divided. While a zygote and embryo are not a person, they are the precursor to a person and to many religious institutions, the destruction of them is wrong. Incidentally, the embryos and other tissues currently being used for ESC research are tissues that would otherwise be discarded in waste; such is the case with in vitro fertilization “left-overs” and umbilical cord blood and placenta (Green, 2011).
Federal funding is no longer a concern under the Obama administration, although, due to economic decline, much funding, outside of what is provided by the federal government is in jeopardy (Lu, 2009). In addition, the fifteen years of debate surrounding the funding of stem cell research may have cost the U.S. an entire generation of scientists who may have dedicated their career to studying stem cells, according to the co-director and co-founder of the Harvard Stem Cell Institute, David Scadden, whose research involves mainly hematopoietic stem cells (Calborn, 2011).
Challenges in “cell-therapy:”
“Cell therapy” is the term for the use of stem cells to replace damaged cells with healthy cells. Identification of HSCs also presents a problem with treatment, as well as the availability of enough HSCs at a time to be effective (“Questions and answers,” 2011). Researchers have been able to extract HSCs from bone marrow in a donor using Granulocyte Colony Stimulating Factors (GCSF). The blood is filtered through a machine that catches CD34+ cells, or cobblestone area-forming cells, and then returns red blood cells. This yields a five to 20% concentration of “true hematopoietic stem cells (“Hematopoietic stem cells,” 2011).”
ESCs also present problems that cannot be ignored within the realm of “cell therapy” treatment. First, as with conception, the conditions of integration must be immaculate for the therapy to be successful (“Hematopoietic stem cells,” 2011). White blood cells fight off foreign cells, for they are designed to determine the difference between self and non-self. This is the cause when the body rejects transplanted tissue (Alters & Alters, 2008). T lymphocytes, a specialized white blood cell that has the capability to differentiate as well, are great for integrating EBCs and fighting off infection, however, they are also the cause for graft-versus-host disease. In order to properly integrate, immune-suppression therapy need take place, which is a dangerous endeavor (“Hematopoietic stem cells,” 2011).
The future of stem cell research:
[Extracting stem cells from a patient]. . . That can become the ultimate, personalized medicine tool kit: a stem cell-based tool kit to study what goes wrong, determine what drug candidates might affect it, and possibly even supply the cells to replenish those lost in the disease.– David Scadden (Clalborn, 2010)
Stem cell research, as it progresses over the next decade or more, will be exploring the plasticity of stem cells and the possibility of using them to grow whole organs, tissues and cure degenerative diseases such as muscular dystrophy and Parkinson’s disease (“Questions and answers,” 2011).
Stem cells found in the brain are almost completely inactive, they barely respond to injury or disease. The use of ESCs to treat mental illness or brain injuries is a real possibility in the future, due to the current support from the federal government (“Questions and answers,” 2011).
In summary:
Should the next president continue funding of ESC research, an assay for identification and/or solution of proliferation become available to scientist and the economy make a full recovery, there will still be challenges ahead for stem cell researchers. For every question answered is bound to inspire even more questions.
As with any research and development of medical treatment, morals and ethics must play a role in regulation and law. People must be protected, donors must be protected and rights must be protected. Conforming to the proper guidelines, the results of stem cell research are seemingly endless. It is with bated breath that the families of fatally ill and mortally wounded patients wait for an answer to their prayers. Stem cell research could quite possibly be that answer.
References:
Alters & Alters (2008) Biology: Understanding Life. Hoboken, NJ.
Clalborn, K. (2011). Federal funding for stem cell research: 15 years of indecision. The Journal of Clinical Investigation, 121(7), 2531.
Green, R. (2001). The stem-cell debate. Retrieved from http://www.pbs.org/wgbh/nova/miracle/stemcells.html
Hematopoietic stem cells. In Stem cell information [world wide web site]. Bethesda, MD: National
Institutes of Health. U.S. Department of Health and Human Services. (2011) [cited Wednesday, November 16, 2011] Available at http://stemcells.nih.gov/info/scireport/chapter5
Lempien, E. (2011, July 28). AAAS welcomes court ruling to allow continued federal funding of
embryonic stem cell research. Retrieved from http://www.aaas.org/news/releases/2011/0728stem_cell.shtml
Lu, A. (2009, March 04). Budget cuts endanger stem-cell research in NJ. The Philadelphia Inquirer, p. A1.
Questions and answers about stem cells. (2011). Retrieved from
http://www.aaas.org/news/press_room/stemcell/faq.shtml
Sabin, B. (2005). Stem cell research-who benefits? who loses?. J@pan Inc, (64), 3.
Sharockman, A. (2010, June 11). Bill mccollum and barack obama see eye-to-eye on stem cell research, rick scott claims. St. Petersburg Times.
Stem cell information [world wide web site]. Bethesda, MD: National Institutes of Health. U.S.
Department of Health and Human Services. (2011) [cited Wednesday, November 16, 2011] Available at http://stemcells.nih.gov/info/health
Townsend, T. (2008, September 26). Mccain stem cell ad irks conservative christians ad never uses the term 'embryonic,' which is at the heart of dispute about stem cells in missouri. St. Louis Post-Dispatch, p. C1.
Tuesday, November 15, 2011
Vaccines, Some Statistics And a Balanced Argument
Is it worth the risk?
When comparing statistics, I think that it is very clear which is the bigger risk between immunizing or denying a child vaccines against common ailments. As an example, according to a report from the Pediatric Academics Society in 2003, an estimated 10.5 million instances of illness and 33,000 deaths annually are prevented because of vaccinations (Vaccines, 2010). In the argument against mandated vaccinations, or immunization in general, you will find that 30,000 cases of adverse effect resulting from vaccines have been reported since 1991, 13% of which were considered “serious ,” to define, resulting in hospitalization, life-threatening, fatal , or causing permanent disability (Vaccines, 2010). In comparing those statistics the more serious risk is clearly in declining the treatment.
In argument against vaccines (I chose the most valid and plausible):
Mandates for school admission are a violation of the first amendment when immunization is unacceptable within the religious facility or following to which a family participates (Vaccines, 2010).
Regulation of food, water and wastes coupled with nutrition and hygiene are sufficient in the prevention of common illness (Vaccines, 2010).
Certain vaccines may cause the illness it is seeking to prevent, lymphatic complications due to immune suppression, brain and spinal cord inflammation, and does not protect against all strains of disease and illness (Vaccines, 2010).
The immune system is weakened by immunization and children need to be able to build antibodies naturally (Vaccines, 2010).
In argument for vaccines (by way of counter-arguments):
No one has the right to endanger the public because of philosophical or religious beliefs, especially in public schools that are federally regulated. Those opposed can choose private schools. However, all 50 states of which mandate immunization also have exceptions of some form for such a reason (Vaccines, 2010).
Hygiene, nutrition and the proper regulation of water, food and waste are promoted similarly in Victoria Australia. In 2006, there were 424 reported instances of influenza. In 2007 immunization was reported to have experienced a dip in popularity, incidentally the reported instances of influenza rose to 1,590 reported instances (Medew, 2008)! As an example, what makes society as safe as it can be is still not as effective as vaccinations and therefore declining is much less likely to protect you from illness or, even death.
The studies that anti-vaccination advocates rely on are often biased, exaggerated and offer false data (Vaccinations, 2010). In 2010 the journal article that sparked the fear of a link between autism and immunization was retracted by the journal that printed it in 1998, The British Medical Journal, and in 2011, released a new article chronicling “elaborate fraud” of the 1998 writer (Vaccinations, 2010). In regards to not protecting against all strains of an illness, HPV was most commonly referenced in the anti-vaccine campaign (Vaccinations, 2010). Every year in the US there are 10,000 diagnoses and 3,700 deaths attributed to cervical cancer. HPV causes two types of cervical cancer, as the second leading cancer killer of women, is it really worth the wager (Vaccines, 2010)?
Vaccines give the natural immune system a boost by introducing the toxin/virus to the body in a safe manner, by deactivating it first. Vaccines seem to be more natural and safer than antibiotics being that antibiotics promote tolerance and build up in the body sometimes having adverse cosmetic effects; allergies are also a possibility of anything meant to cure (Alters & Alters, 2008).
Do I immunize?
I have always and will always immunize. I made the benefits and risks an independent study (as well as other health concerns) through out the duration of my first pregnancy because I was very irrationally afraid I would lose my son. Also, the doctor's office I was frequenting, as well as the hospital I delivered at, provided literature about the different immunizations offered and when. I think the bigger risk is not immunizing. I am comforted by the statistics. I don't think vaccines are 100% safe just as antibiotics are not, but I will not gamble on my children's health. I would rather get every vaccine offered and have them be tired or sore for a day or a week and never have to deal with rubella or polio.
References:
Alters & Alters (2008) Hoboken, NJ. Wiley & Sons. p.526
Injection of good sense. (2010, July 20). The Globe and Mail, p. A14.
Medew, J. (2008, October 27). Don't dodge the needle, doctors say. The Age, p. 3.
Vaccines. (2010, January 07). Retrieved from http://vaccines.procon.org/
When comparing statistics, I think that it is very clear which is the bigger risk between immunizing or denying a child vaccines against common ailments. As an example, according to a report from the Pediatric Academics Society in 2003, an estimated 10.5 million instances of illness and 33,000 deaths annually are prevented because of vaccinations (Vaccines, 2010). In the argument against mandated vaccinations, or immunization in general, you will find that 30,000 cases of adverse effect resulting from vaccines have been reported since 1991, 13% of which were considered “serious ,” to define, resulting in hospitalization, life-threatening, fatal , or causing permanent disability (Vaccines, 2010). In comparing those statistics the more serious risk is clearly in declining the treatment.
In argument against vaccines (I chose the most valid and plausible):
Mandates for school admission are a violation of the first amendment when immunization is unacceptable within the religious facility or following to which a family participates (Vaccines, 2010).
Regulation of food, water and wastes coupled with nutrition and hygiene are sufficient in the prevention of common illness (Vaccines, 2010).
Certain vaccines may cause the illness it is seeking to prevent, lymphatic complications due to immune suppression, brain and spinal cord inflammation, and does not protect against all strains of disease and illness (Vaccines, 2010).
The immune system is weakened by immunization and children need to be able to build antibodies naturally (Vaccines, 2010).
In argument for vaccines (by way of counter-arguments):
No one has the right to endanger the public because of philosophical or religious beliefs, especially in public schools that are federally regulated. Those opposed can choose private schools. However, all 50 states of which mandate immunization also have exceptions of some form for such a reason (Vaccines, 2010).
Hygiene, nutrition and the proper regulation of water, food and waste are promoted similarly in Victoria Australia. In 2006, there were 424 reported instances of influenza. In 2007 immunization was reported to have experienced a dip in popularity, incidentally the reported instances of influenza rose to 1,590 reported instances (Medew, 2008)! As an example, what makes society as safe as it can be is still not as effective as vaccinations and therefore declining is much less likely to protect you from illness or, even death.
The studies that anti-vaccination advocates rely on are often biased, exaggerated and offer false data (Vaccinations, 2010). In 2010 the journal article that sparked the fear of a link between autism and immunization was retracted by the journal that printed it in 1998, The British Medical Journal, and in 2011, released a new article chronicling “elaborate fraud” of the 1998 writer (Vaccinations, 2010). In regards to not protecting against all strains of an illness, HPV was most commonly referenced in the anti-vaccine campaign (Vaccinations, 2010). Every year in the US there are 10,000 diagnoses and 3,700 deaths attributed to cervical cancer. HPV causes two types of cervical cancer, as the second leading cancer killer of women, is it really worth the wager (Vaccines, 2010)?
Vaccines give the natural immune system a boost by introducing the toxin/virus to the body in a safe manner, by deactivating it first. Vaccines seem to be more natural and safer than antibiotics being that antibiotics promote tolerance and build up in the body sometimes having adverse cosmetic effects; allergies are also a possibility of anything meant to cure (Alters & Alters, 2008).
Do I immunize?
I have always and will always immunize. I made the benefits and risks an independent study (as well as other health concerns) through out the duration of my first pregnancy because I was very irrationally afraid I would lose my son. Also, the doctor's office I was frequenting, as well as the hospital I delivered at, provided literature about the different immunizations offered and when. I think the bigger risk is not immunizing. I am comforted by the statistics. I don't think vaccines are 100% safe just as antibiotics are not, but I will not gamble on my children's health. I would rather get every vaccine offered and have them be tired or sore for a day or a week and never have to deal with rubella or polio.
References:
Alters & Alters (2008) Hoboken, NJ. Wiley & Sons. p.526
Injection of good sense. (2010, July 20). The Globe and Mail, p. A14.
Medew, J. (2008, October 27). Don't dodge the needle, doctors say. The Age, p. 3.
Vaccines. (2010, January 07). Retrieved from http://vaccines.procon.org/
Meaningless
I wish.
My attempt at downplaying disappointment.
I was confident I had found the perfect position.
The interview went amazing and I bristled at minimum wage but felt secure in the possibility of a review and possible raise every 90 days..
So I really put my best foot forward, I went in asking questions, did as I was asked, did a little extra and offered to do more.
My boss is/was impressed.
I got a little flustered when my client became hostile. I handled it well despite my anxiety and put it in the paperwork, going directly to my boss for communication since there was no other form.
Today I find out my client is going back to rehab and I am so incredibly disappointed.
So here is what I have to do.
Senior care is not my preferred anyway, I would prefer someone who is developmentally disabled, specifically with down syndrome.
Now I have the availability when that job comes along.
My client was hostile, possibly drama-filled and approaching dementia and that is stressful and brings out my anxiety.
I've had several clients who were a pleasure to work for and now I can find another like that.
The pay was minimum wage and the drive was out of town. Now I can be available if a client becomes available through my company that is close by or I can be available if another company offers me better pay.
The hours were right but there wasn't enough of them, this opens me up for something with at 20-25 hours per week.
At least I found care.com and sitter city and those allow me to browse at my convenience and possibly get hits as I already have- though I have not heard back form anyone yet.
Of course the hope is that I will hear back from someone and it will be THE job for me until I get my bachelor's and can pursue something amazing, significant and high-paying.
I feel better already. ^.^
My attempt at downplaying disappointment.
I was confident I had found the perfect position.
The interview went amazing and I bristled at minimum wage but felt secure in the possibility of a review and possible raise every 90 days..
So I really put my best foot forward, I went in asking questions, did as I was asked, did a little extra and offered to do more.
My boss is/was impressed.
I got a little flustered when my client became hostile. I handled it well despite my anxiety and put it in the paperwork, going directly to my boss for communication since there was no other form.
Today I find out my client is going back to rehab and I am so incredibly disappointed.
So here is what I have to do.
Senior care is not my preferred anyway, I would prefer someone who is developmentally disabled, specifically with down syndrome.
Now I have the availability when that job comes along.
My client was hostile, possibly drama-filled and approaching dementia and that is stressful and brings out my anxiety.
I've had several clients who were a pleasure to work for and now I can find another like that.
The pay was minimum wage and the drive was out of town. Now I can be available if a client becomes available through my company that is close by or I can be available if another company offers me better pay.
The hours were right but there wasn't enough of them, this opens me up for something with at 20-25 hours per week.
At least I found care.com and sitter city and those allow me to browse at my convenience and possibly get hits as I already have- though I have not heard back form anyone yet.
Of course the hope is that I will hear back from someone and it will be THE job for me until I get my bachelor's and can pursue something amazing, significant and high-paying.
I feel better already. ^.^
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